Impact the alcoholic and aqueous extract, clove (Syzygium aromaticum) clove oil and sodium chloride on growth of Candida albicans
Abstract:
Candidiasis is an acute or chronic infection that is always caused by Candida species, normal commensals of the oral mucous membranes of healthy individuals. Between October 2024 and March 2025, we collected a number of specimens from oral thrush patients visiting dental clinics in Al-Najaf Governorate (n = 50). These specimens were then transferred to the Advanced Mycology Laboratory, Faculty of Science University of Al-Kufa for diagnostic and experimental purposes. The objective of the present study was to isolate and identify Candida albicans from various clinical cases by means of different diagnostic methods including direct microscopy and microbiological culture. Moreover, Inhibitory activities of alcoholic extract of clove oil in different concentrations (1%, 2% and 3%), Clove at four levels (0.25g,0.5g,50g and l g) and sodium chloride were examined over Candida albicans growth In the present study, we evaluated antifungal activity of these agents (alcoholic and aqueous extracts of clove oil, clove and sodium chloride) against Candida albicans using well diffusion method and interpreted findings according to Statistical analysis. In the Study the effect of antifungal of alternative material in concentration (2.5,5,10)mg\ml from clove the Inhibition zone(mm) of candida albicans for 7 isolate are (3,4,6),(7,6,8),(3.5,3,4),(5.5,7,9),(4,3.5,4), (4,6,9),(4.5,8,10) the effect of antifungal of alternative material in concentration(2.5,5,10)mg\ml from clove oil Inhibition zone(mm) of candida albicans for 7 isolate (4,3.5,5),(3.5,5,6), (4,6,7),(4.5,5.5,7),(3.5,4,5),(3,6,7), (4,5,6) the effect of antifungal of alternative material in concentration (2.5,5,10)mg\ml from sodium chloride Inhibition zone(mm) of candida albicans for 7 isolate( 2,4,5),(3,4,4.5),(3.5,3,4),(4,6,6.5), (3,3.5,4.5), (3,5,7), (3,4,6) the effect of antifungal of alternative material in concentration (2.5,5,10)mg\ml from alcoholic extract clove Inhibition zone(mm) of candida albicans for 7 isolate (16,17,18),(14,15,20), (16,17,18),(10,14,20),(12,15,20), (6,9,17),(6,7.5,13) the effect of antifungal of alternative material in concentration(2.5,5,10)mg\ml from aqueous extract clove Inhibition zone(mm) of candida albicans for 7 isolate (13,14,16),(17,19,24),(11,12,15),(4.5,6,10), (10,14,20),(12,15,20), (13,14,25)
KeyWords:
Candida albicans, Oral candidiasis, Syzygium aromaticum, Antifungal activity, Plant extract, Well diffusion method
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