International Journal of Medical Science and Pharmaceutical Research

Introduction: Breast cancer is the most common cancer in women; it often metastasizes to bone, liver, and lungs. However, atypical secondary sites can be difficult to diagnose and require special attention. Early and specialized management improves survival and, above all, quality of life.

Case Study: We report the case of patient M.A., aged 55, with no known significant medical history, who was treated in 2017 for invasive lobular carcinoma of the left breast (Luminal B). She underwent radical surgery, adjuvant chemotherapy and radiotherapy, and hormone therapy.

In March 2023, follow-up examination revealed multiple suspicious ipsilateral axillary lymph nodes. Radiological evidence of these lymph nodes persisted despite multiple surgical revisions, leading to the initiation of two lines of therapy, with which the patient remained stable for one year.

In May 2025, she presented with a swelling on the anterior aspect of her ipsilateral arm. Further investigation suggested a secondary soft tissue metastasis of breast origin, confirmed by immunohistochemistry (HER2+). Three lines of therapy were initiated, but without therapeutic benefit, hence the indication for radical surgery, specifically amputation of the left upper limb.

Conclusion: This case illustrates that the symptoms of atypical metastases can be difficult to diagnose, highlighting the importance of regular and close clinical monitoring to improve the quality of care and survival rates.

breast; cancer; atypical location; arm; axillary lymphadenopathy

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