International Journal of Medical Science and Pharmaceutical Research

Climate change, primarily driven by human activities such as fossil fuel combustion and deforestation, is significantly altering global weather patterns and ecosystems. This review explores the multifaceted impact of climate change on infectious disease patterns and management, emphasizing the increased risks to human health. Climate change leads to rising temperatures, altered precipitation, and extreme weather events, which collectively exacerbate the transmission of infectious diseases, including vector-borne, waterborne, and foodborne illnesses. Vulnerable populations, including marginalized communities and those with pre-existing health conditions, face heightened exposure to these health threats. The review discusses the mechanisms of zoonotic spillover, highlighting how habitat disruption and increased human-wildlife interactions facilitate the emergence and spread of infectious diseases. Key examples illustrate the relationship between climate variability and disease outbreaks, such as hantavirus and malaria. Mitigation and adaptation strategies are critically examined, advocating for a comprehensive approach that includes reducing greenhouse gas emissions, enhancing carbon sinks, and implementing policies that promote sustainable land use and public health preparedness. The necessity for international cooperation and a One Health framework is emphasized, aiming to integrate human, animal, and environmental health. As climate change continues to pose unprecedented challenges, this review underscores the urgent need for coordinated action to protect global health and prevent future pandemics.

Climate change, Disease, Ecology, Prevention, strategies, Vector-Borne

1. Balan, N., & George, G. (2025). Feverish Future: Infectious Disease Risks in the Age of Climate Change. Biosciences Biotechnology Research Asia, 22(2), 449–458. https://doi.org/10.13005/bbra/3375. 
2. Better Health Channel. (2021). Climate change and health. Vic.gov.au. https://www.betterhealth.vic.gov.au/health/HealthyLiving/climate-change-and-health. 
3. Borham, A., Kadria Abdel Motaal, Nour ElSersawy, Ahmed, Y. F., Mahmoud, S., Abobaker Salem Musaibah, & Anwar Abdelnaser. (2025). Climate Change and Zoonotic Disease Outbreaks: Emerging Evidence from Epidemiology and Toxicology. International Journal of Environmental Research and Public Health, 22(6), 883–883. https://doi.org/10.3390/ijerph22060883. 
4. Bryan, K., Ward, S., Roberts, L., White, M. P., Landeg, O., Taylor, T., & McEwen, L. (2020). The health and well-being effects of drought: assessing multi-stakeholder perspectives through narratives from the UK. Climatic Change, 163(4), 2073–2095. https://doi.org/10.1007/s10584-020-02916-x. 
5. Caminade, C., McIntyre, K. M., & Jones, A. E. (2019). Impact of recent and future climate change on vector-borne diseases. Annals of the New York Academy of Sciences, 1436(1), 157–173. https://doi.org/10.1111/nyas.13950. 
6. CDC. (2024, April 17). Vector-Borne Diseases. Climate and Health. https://www.cdc.gov/climate-health/php/effects/vectors.html. 
7. de Souza, W., & Weaver, S. C. (2024). Effects of Climate Change and Human Activities on vector-borne Diseases. Nature Reviews Microbiology, 22(22). https://doi.org/10.1038/s41579-024-01026-0. 
8. DNDi | Best science for the most neglected. (2024, April 15). Dndi.org. https://dndi.org/. 
9. ECDC. (2021, July 20). Risk of infectious diseases in flood-affected areas from the European Union. European Centre for Disease Prevention and Control. https://www.ecdc.europa.eu/en/news-events/risk-infectious-diseases-flood-affected-areas-european-union. 
10. Esposito, S., Principi, N., & Leung, C. C. (2023). Climate change and its impact on infectious diseases: A global review. Journal of Infection and Public Health, 16(4), 567–574.
11. Edward, M., Heniedy, A. M., Saminu, A., Florence Mary, J. J., Ahmed, D. A., Engmann, S. T., Onyeaghala, C., & Shah, S. (2024). Climate Change and contagion: the Emerging Threat of Zoonotic Diseases in Africa. Infection Ecology & Epidemiology, 15(1). https://doi.org/10.1080/20008686.2024.2441534. 
12. Ellwanger, J. H., & Chies, J. A. B. (2021). Zoonotic spillover: Understanding Basic Aspects for Better Prevention. Genetics and Molecular Biology, 44(1). https://doi.org/10.1590/1678-4685-GMB-2020-0355. 
13. Esposito, M., Turku, S., Lehrfield, L., & Shoman, A. (2023). The Impact of Human Activities on Zoonotic Infection Transmissions. The Impact of Human Activities on Zoonotic Infection Transmissions, 13(10), 1646–1646. https://doi.org/10.3390/ani13101646. 
14. Gertler, M., Dürr, M., Renner, P., Poppert, S., Askar, M., Breidenbach, J., Frank, C., Preußel, K., Schielke, A., Werber, D., Chalmers, R., Robinson, G., Feuerpfeil, I., Tannich, E., Gröger, C., Stark, K., & Wilking, H. (2015). Outbreak of cryptosporidium hominis following river flooding in the city of Halle (Saale), Germany, August 2013. BMC Infectious Diseases, 15(1). https://doi.org/10.1186/s12879-015-0807-1. 
15. Harris, J., & Roach, B. (2021). ENVIRONMENTAL AND NATURAL RESOURCE ECONOMICS: A CONTEMPORARY APPROACH. https://www.bu.edu/eci/files/2021/06/Chapter-13-Global-Climate-Change-Policy-Responses.pdf. 
16. How climate change affects foodborne diseases | News. (2024). Wellcome. https://wellcome.org/news/how-climate-change-affects-foodborne-diseases. 
17. IPBES. (2019). Global assessment report on biodiversity and ecosystem services of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services. IPBES. https://doi.org/10.5281/zenodo.6417333. 
18. IPCC. (2023). AR6 Synthesis Report: Climate Change 2023. Www.ipcc.ch; IPCC. https://www.ipcc.ch/report/ar6/syr/. 
19. Irakoze Mukamana, & Kiu Publication Extension. (2024). The Impact of Climate Change on Infectious Disease Spread. EURASIAN EXPERIMENT JOURNAL of PUBLIC HEALTH , 5(2), 41–44. https://www.researchgate.net/publication/384455172_The_Impact_of_Climate_Change_on_Infectious_Disease_Spread. 
20. Melaram, R., Newton, A. R., & Chafin, J. (2022). Microcystin Contamination and Toxicity: Implications for Agriculture and Public Health. Toxins, 14(5), 350. https://doi.org/10.3390/toxins14050350. 
21. Mulder, A. C., Pijnacker, R., de Man, H., van de Kassteele, J., van Pelt, W., Mughini-Gras, L., & Franz, E. (2019). “Sickenin’ in the rain” – increased risk of gastrointestinal and respiratory infections after urban pluvial flooding in a population-based cross-sectional study in the Netherlands. BMC Infectious Diseases, 19(1). https://doi.org/10.1186/s12879-019-3984-5. 
22. NASA Climate Kids :: What is “global climate change”? (2018). NASA.gov; NASA. https://climatekids.nasa.gov/climate-change-meaning/. 
23. National Wildlife Federation. (2019). Climate Policy Recommendations | National Wildlife Federation. National Wildlife Federation. https://www.nwf.org/Our-Work/Climate/Climate-Change/Policy. 
24. Neves, R. A. F., Nascimento, S. M., & Santos, L. N. (2021). Harmful algal blooms and shellfish in the marine environment: an overview of the main molluscan responses, toxin dynamics, and risks for human health. Environmental Science and Pollution Research International, 28(40), 55846–55868. https://doi.org/10.1007/s11356-021-16256-5. 
25. Ojeyinka, O. T., Omaghomi, T. T., Ojeyinka, O. T., & Omaghomi, T. T. (2024). Climate change and zoonotic diseases: a conceptual framework for predicting and managing health risks in the USA. GSC Biological and Pharmaceutical Sciences, 26(3), 027–036. https://doi.org/10.30574/gscbps.2024.26.3.0084. 
26. Pan American Health Organization. (2023). Climate Change and Health - PAHO/WHO | Pan American Health Organization. Www.paho.org. https://www.paho.org/en/topics/climate-change-and-health. 
27. Segala, F. V., Guido, G., Stroffolini, G., Masini, L., Cattaneo, P., Moro, L., Motta, L., Gobbi, F., Nicastri, E., Vita, S., Iatta, R., Otranto, D., Locantore, P., Occa, E., Putoto, G., Saracino, A., & Di Gennaro, F. (2025). Insights into the ecological and climate crisis: Emerging infections threatening human health. Acta Tropica, 262, 107531. https://doi.org/10.1016/j.actatropica.2025.107531. 
28. Thomson, M. C., & Stanberry, L. R. (2022). Climate Change and Vectorborne Diseases. New England Journal of Medicine, 387(21), 1969–1978. https://doi.org/10.1056/nejmra2200092. 
29. UNDP. (2024, January 30). What is climate change adaptation and why is it crucial? UNDP Climate Promise. https://climatepromise.undp.org/news-and-stories/what-climate-change-adaptation-and-why-it-crucial. 
30. UNICEF. (2024). Water, sanitation and hygiene (WASH) and climate change. Www.unicef.org. https://www.unicef.org/wash/climate
31. United Nations. (2022). Introduction to Mitigation. Unfccc.int. https://unfccc.int/topics/introduction-to-mitigation. 
32. United Nations. (2025). What Is Climate Change? United Nations. https://www.un.org/en/climatechange/what-is-climate-change. 
33. Water and food-borne diseases — European Climate and Health Observatory. (2025). Climate-Adapt.eea.europa.eu. https://climate-adapt.eea.europa.eu/en/observatory/evidence/health-effects/water-and-food-borne-diseases. 
34. Weilnhammer, V., Schmid, J., Mittermeier, I., Schreiber, F., Jiang, L., Pastuhovic, V., Herr, C., & Heinze, S. (2021). Extreme weather events in europe and their health consequences – A systematic review. International Journal of Hygiene and Environmental Health, 233, 113688. https://doi.org/10.1016/j.ijheh.2021.113688. 
35. Wikipedia Contributors. (2019, July 7). Climate change mitigation. Wikipedia; Wikimedia Foundation. https://en.wikipedia.org/wiki/Climate_change_mitigation. 
36. World Bank. (2024, November 16). Health and Climate Change. World Bank. https://www.worldbank.org/en/topic/health/brief/health-and-climate-change. 
37. World Health Organization. (2019, August 9). Climate change. World Health Organization; World Health Organization: WHO. https://www.who.int/health-topics/climate-change#tab=tab_1.